regulatory mechanism remain unclear. Moreover, the role of alternative polyadenylation, a posttranscriptional regulator of cell fate, in monocyte/macrophage fate decisions during atherogenesis is not entirely understood.
METHODS:polyadenylation patterns was estimated in human plaques via bulk RNA sequencing.
accumulation of these transitional macrophages were associated with atherosclerosis progression in humans.
CONCLUSIONS:
Our study reveals that Srsf3-dependent generation of long 3′ untranslated region is required for efficient mitochondrial translation, which promotes mature phagocytic macrophage formation, thereby playing a protective role in atherosclerosis.
It is known that organelles communicate with each other to maintain cellular homeostasis. However, how signals are transduced among organelles to determine the immune functions of macrophages has not been clear yet.
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